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Histological examination of liver tissue plays a crucial role in confirming the diagnosis, excluding alternate or comorbid etiologies, distinguishing AIH from ASC/overlap syndrome, and assessing fibrosis stage for prognostication

These haemichromes are extremely hazardous and may initiate the production of ROS, including hydroxyl radicals, thereby causing oxidative damage in erythroid cells (Matte and De Franceschi, 2019)

We previously reported that in addition to its support of antioxidant function, the glutathione cycle also serves as a reservoir of intracellular neural glutamate (16)

While dimerization and oligomerization of integral membrane proteins remained a generally accepted concept, translating this to GPCRs remained elusive (Klingenberg, 1981)

In another aspect of the invention, a method of targeted drug delivery of an effective amount of an agent, or a pharmaceutical acceptable carrier comprising an agent, to a target site that is protected by a specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes, is provided wherein: a) the agent or the pharmaceutical acceptable carrier is conjugated to a ligand, that facilitates the specific binding to and internalization by an internalizing GSH uptake receptor of the target site, thereby forming the conjugate as defined above